"Antacids May Mask the Real Problem ... gastroesophageal reflux disease ... heart attack ... “Therefore, before you rely on antacids to treat your symptoms, it is very important to be evaluated by a healthcare provider to ensure you don’t have a more serious health condition masking itself as indigestion,” says Dr. Dumot."
"PPIs are generally considered safe, but concerns about long-term use have been raised over the years—especially as they have been widely used and sometimes, overused, doctors say. Research has associated these medications with an increased risk of fracture, cardiovascular disease, dementia, chronic kidney disease, vitamin and mineral deficiencies, and infection."
"Some research suggests that overuse of H-2 blockers can cause headaches, constipation and nausea, but their long-term use has not been extensively studied."
"While PPIs are helpful in managing severe heartburn, they are not recommended for more than a 14-day treatment. Recent studies show that overuse of PPIs can be harmful to your health and should not be used long-term. Side effects of proton pump inhibitors include infections, bone fractures and vitamin and mineral deficiencies. Research has even connecting extended PPI drug use to increased risk of stomach cancer."