On the other hand, see the "dualism" section below.
This Backstory episode points out that most land in America has been affected by humans for many hundreds of years. (slash-and-burn was used before the Neolithic)
The Wilderness Act of 1963 defines wilderness as land "with the imprint of man’s work substantially unnoticeable". So the goal is more to appear to humans to be minimally used. (of course, we know that federal preserves serve dual purposes: human recreation and biological conservation, so appearance isn't the only issue)
There are some other philosophical issues:
More things to read: